AmaZulu will host high-flying University of Pretoria in an Absa Premiership match at King Zwelithini Stadium on Wednesday, 7 November 2012, kick-off at 19h30.
AmaZulu held champions Orlando Pirates to a goalless draw in their last league outing, picking up their first point on the road.
The Durban side will be looking to improve on a home record which has seen them collect just four points from as many matches so far this season.
Usuthu are placed 16th on the Absa Premiership log with five points from eight matches.
University of Pretoria defeated Bloemfontein Celtic 2-1 away from home in their last league outing.
The top-flight rookies have a 100 percent record away from home so far this season, with four wins from as many matches.
AmaTuks are placed second on the Absa Premiership log with 15 points from eight matches.
This will be the first competitive league meeting of AmaZulu and University of Pretoria.